Difference between nephrotic and nephritic syndrome compare. The many different causes of glomerular disease can be generally classified into one of three major syndromes. Today we are going to dive into the topic of nephrotic and nephritic syndromes. Nephrotic syndrome is just a clinical face of glomerular injury. The nephrotic syndrome is defined by a urinary protein level exceeding 3. At the turn of the century, clinicians distinguished a nephritic syndrome of i. Thickening of the glomerular basement membrane and kimmelstielwilson lesions are seen on light microscopy.
The nephrotic syndrome is a distinct abnormal clinical and biochemical entity characterized by edema, massive proteinuria, hypoalbuminemia and hypoproteinemia, and hyperlipemia and hypercholesterolemia. However, there was significantly lower posttherapy gastric pge2 concentrations in the prednisolone group. Ashley jefferson1 1division of nephrology, department of medicine, university of washington school of medicine, seattle, washington, usa. Embrace the kidney again as we sort the different diagnostics, managements, and prognosis for these two pathologies. You can also join our mailing list and get a pdf copy of our show notes every week. Etiology history physical exam laboratory primary glomerular disease, e. The supernate was yellow in 10 of the urines and slightly brownish in one. In a nephritic syndrome, all of these occur plus there is hematuria or blood in the urine. Nephrotic syndrome, nephritic syndrome, and asymptomatic renal disease. The main causes share intraglomerular inflammation and include vasculitis, antibodymediated damage, and immune complex disease. Rbc casts form through the congregation of proteins and rbcs inside the tubules. Nephritic syndrome oxford medicine oxford medicine online. Aug 16, 2017 summary glomerulonephritis vs nephrotic syndrome.
Hey guys, in todays video we are going to take on the nephritic syndrome, the nephritic syndrome is essentially a inflammatory disorder of the glomeruli wi. Nov 07, 20 nephrotic vs nephritic syndrome nephrotic and nephritic syndromes are common childhood conditions presenting with oedema and proteinuria. What is the difference between nephritic and nephrotic. Because nephritic syndrome is a syndrome and not a disease, the prognosis depends on the underlying cause. The pathophysiology of the nephrotic syndrome jama.
Nephrotic proteinuria was defined by a daily urine protein excretion of more than 3. Nephritic syndrome an overview sciencedirect topics. This is mostly suitable for the medical students to prepare their lessons. Glomerular injury leads to impairment of the selective filtering properties of the kidney and reduction in the glomerular filtration rate gfr. Laboratory findings include hematuria, proteinuria nephrotic syndrome is more of protein proteinuria loss while the nephritic syndrome is more of blood loss hematuria. Summary glomerulonephritis vs nephrotic syndrome both nephritic syndrome and nephrotic syndrome are renal disorders which share few common symptoms. However, these patients usually have a nephritic pattern with haematuria and red cell casts as the predominant feature. Diabetic glomerulonephritis is the only other answer that is a nephrotic syndrome, the rest are nephritic syndromes. Difference between nephrotic and nephritic syndrome. Minimal change disease accounts for 90% of nephrotic syndrome cases in children nephrotic syndrome in children, management. The aim of this study was to compare clinical and laboratory features of children with acute poststreptococcal glomerulonephritis and steroid sensitive nephrotic syndrome.
Nephrotic syndrome may appear as a primary idiopathic renal disease or occur in association with any of a. Generally, the prognosis of nephritic syndrome in children is better than it is in adults. Recognize complications associated with nephrotic syndrome, including those resulting from diuretic therapy. Pulmonary or cerebral oedema may complicate acute nephritic syndrome. A case is presented of an immunocompetent patient aged 15 with clinical and laboratory indications of nephrotic nephritic. Nephrotic syndrome versus nephritic syndrome current. A patient complains of excessively frothy urine when he uses the toilet in the morning. Nephrotic syndrome ns, defined as the concurrent presence of hypoalbuminemia, proteinuria, hyperlipidemia, and fluid accumulation in interstitial spaces andor body cavities, is a rare complication of glomerular disease in dogs, cats, and people. Pdf corticosteroids therapy and peptic ulcer disease in. Nephritic syndrome and membranoproliferative glomerulonephritis. An overview of nephrotic and nephritic syndrome, including key clinical features.
Nephrotic and nephritic syndrome dr nabiha najati 2020 nephrotic syndrome nephrotic syndrome dr. Identify the cause of hyponatremia in nephrotic syndrome. In todays article we will cover glomerulonephritis made easy, nephritis and. Roger seheult, md of illustrates the key differences between the nephrotic and nephritic syndromes. Nephrotic syndrome and a maculopapular rash american. Affected animals frequently have markedly abnormal. Assessment of nephrotic syndrome differential diagnosis. Nephrotic syndrome in infants and children salud infantil. Nephrotic syndrome is defined by a triad of clinical features.
Srinath kumar md group head, narayana hrudayalaya president, society emergency medicine india member special advisory board for emergency medicine, dnb associate editor national journal of emergency medicine. Hypertension, nephrotic syndrome, and acute kidney injury are very rare at this stage. Nephrotic syndrome is a general type of kidney disease seen in children. Nephrotic syndrome is a group of symptoms that show your kidneys are not working as well as they should. The sedimentation rate of the urinary sediment was slow. I have also included the pdf download link of the power point presentation. Nephrotic syndrome can affect children of any age, from infancy to adolescence, and is most commonly seen among schoolaged children and adolescents. Pdf acute glomerulonephritis mimicking nephrotic syndrome. Type i idiopathicprimary vs secondary dense deposit disease formerly type ii mpgn type i mpgn.
Nephrotic syndrome in pregnancy poses risks with both. Basic information nephrotic syndrome ns reflects glomerular dysfunction causing proteinuria without compromising gfr occurs at all ages but is most prevalent in children between the ages 1. Dec 26, 20 clinical picture of mpgn nephrotic syndrome is present in 50% of cases. Weve also just launched an osce flashcard collection which contains over 800 cards. Nephrotic syndrome is a disease of the kidney while nephritic syndrome is a disease of the glomeruli. Pediatric nephrotic syndrome adam goldstein howard trachtman, m. According to the cdc, nephritisnephrosis nephritic syndrome was the 9th leading cause of death in the united states in 2017. Nephrotic and nephritic syndromes pathoma flashcards. The definition of nephrotic syndrome includes both massive proteinuria.
We have examined 30 children with acute poststreptococcal glomerulonephritis and 17 children with steroid sensitive nephrotic. These symptoms include too much protein in your urine, not enough protein in your blood, too much fat or cholesterol in your blood, and swelling. However, there may be considerable overlap in their clinical presentation with some diseases presenting with components of both syndromes. A comparison between nephritic and nephrotic syndrome from professor hossam mowafy internal medicine textbook nephrology section. Nephrotic syndrome may appear as a primary idiopathic renal disease or occur in association with any of a number of systemic conditions and hereditary diseases.
Most commonly nephritic, but severe forms can also be nephrotic. Difference between glomerulonephritis and nephrotic syndrome. Start studying nephrotic and nephritic syndromes pathoma. Genetic studies in children with familial nephrotic syndrome have identified.
Mar, 2021 nephrotic vs nephritic syndrome if youd like to support us and get something great in return, check out our osce checklist booklet containing over 100 osce checklists in pdf format. Mpgn can also present as nephrotic syndrome and has a generally progressive clinical course with poor outcome. Describe the complications of nephrotic and nephritic syndromes. Both terms refer to a collection of symptoms rather than a true diagnosis. But the fine line which makes them two separate disease entities is drawn across the degree of proteinuria, if the protein loss is higher than 3. Hematuria, hypertension, or azotemia may or may not be present. Nephrotic syndrome can be inherited from a number of genetic mutations that lead to defects in various regions of the glomerular. Formulate a differential diagnosis of nephrotic syndrome with and without hematuria. Downloaded by australian catholic university at 07. Aug 18, 2020 nephritic and nephrotic syndromes refer to clinical presentations of renal disease specifically glomerulonephritis. Combined nephritic and nephrotic disorders flashcards. Nephrotic and nephritic syndromes pathoma flashcards quizlet. How do you make these lists hang together in a way that you can remember.
Nephrotic nephritic picture nephrotic syndrome up to 10% of ns in children and young adults hematuria or non nephrotic range proteinuria in some. Eleven grossly bloody urines were obtained from seven children with nephrosis. If moderate glomerular injury, it will cause nonselective proteinuria without generalized edemas, lipiduria and hyperlipidemia. Nephrotic and nephritic syndrome renal pathology by dr. Difference between glomerulonephritis and nephrotic. Account suspended nephritic syndrome, nursing study. Feb 04, 2020 nephrotic syndrome versus nephritic syndrome both nephritis and nephrosis are among the bodys responses to injury or illness affecting the kidneys. Nephritic flares are predictors of bad longterm renal outcome in. I also believe that this document will help the teachers to arrange the lectures. We talk about all of these fascinating topics and more. Both nephritic syndrome and nephrotic syndrome are renal disorders which share few common symptoms. Learn vocabulary, terms, and more with flashcards, games, and other study tools. The thing to remember for this one is massive proteinuria. Nephritic syndrome is also called glomerulonephritis.
Nephritic syndrome can present with oliguria, hypertension, and hematuria colacolored urine. The terms used to describe renal disease, and glomerulonephritis in particular can be confusing. If you want to include any informations here, feel free to write me. Nephrotic range proteinuria is defined as protein excretion 3. Nephrotic syndrome is more of protein proteinuria loss while the nephritic syndrome is more of blood loss hematuria. In the past, roelans is credited with the first clinical description of nephrotic syndrome.
Booklet containing over 100 osce checklists in pdf format. The differential diagnosis of membranous glomerulopathy and a rash includes systemic diseases systemic lupus erythematosus, sjogren syndrome, and sarcoidosis, infections hepatitis b and c virus, human immunodeficiency virus hiv, syphilis, schistosomiasis, and filariasis, malignancies carcinoma, leukemia. Assessment of nephrotic syndrome differential diagnosis of. The nature and severity of the defect ie, underlying disease and pathologic lesion determine the quantity of red blood cells rbc.
While the nephrotic syndrome is mediated by damage to the podocyte an epithelial cell and the glomerular basement membrane gbm, nephritic syndrome occurs as a result of inflammatory damage to the renal endothelium. Nephritic flares are predictors of bad longterm renal. There were no differences in the occurrence of endoscopic peptic ulcers 1. Pediatric nephrotic syndrome national kidney foundation. In addition to nephrotic syndrome, our patient presented with a maculopapular rash. Ada doctors explain its symptoms, causes, how it differs from nephrotic syndrome, diagnosis, and treatment. By contrast, nephrotic syndrome is characterized by only proteins proteinuria moving into the urine. Causes and pathophysiology of nephrotic syndrome in childhood. Nephrotic syndrome is characterized by severe proteinuria, i. Seventy to ninetysix per cent of the erythrocytes were well preserved, with an average of 84%. Segmental vs global approach to glomerular disease. You might do this by remembering that nephrotic and protein both have an o in them. One of the defining features used to determine the difference between nephritic and nephrotic syndromes is the amount of protein in the urine.
Understand the various factors that affect the prognosis of nephrotic syndrome. Differential diagnosis of nephritic and nephrotic syndroms. Nephrotic vs nephritic syndrome if youd like to support us and get something great in return, check out our osce checklist booklet containing over 100 osce checklists in pdf format. Diagnosis and management charles kodner, md, university of louisville school of medicine, louisville, kentucky i n nephrotic syndrome, a variety of disorders cause. Oct 20, 2020 nephrotic syndrome is an important clinical condition affecting both children and adults. The upcoming article will clear out difference via a table, differential diagnosis of the two syndromes and how to interpret reports to find out which one is. Discover medical cases from every specialty their views and advice download now. Nephritic syndrome is characterized by glomerular capillary damage leading to. Nephrotic vs nephritic syndrome renal geeky medics. Laboratory findings include hematuria, proteinuria nephrotic syndrome is an important clinical condition affecting both children and adults.
We have examined 30 children with acute poststreptococcal glomerulonephritis and 17 children with steroid sensitive nephrotic sy. This video will explain further on the two syndromes of kidney. Difference between nephrotic syndrome and nephritic. Jan 18, 2021 for a comparison of nephrotic and nephritic syndrome see nephrotic vs. Studies suggest that the pathogenesis of edema in individual patients may occur via widely variable. Nephrotic syndrome vs nephritic syndrome explained nephritic vs. Nephrotic vs nephritic syndrome nephrotic syndrome nephrotic syndrome is a condition involving the loss of significant volumes of protein via the kidneys proteinuria which results in hypoalbuminaemia. As those of us in the healthcare profession, or in healthcare professional school know. Edema may also be present, although it is not nearly as severe as in nephrotic syndrome. Arterial hypertension was defined as a supine diastolic blood pressure higher than 90 mm hg. The prevalence worldwide is approximately 16 cases per 100,000 children with an incidence of 2 to 7 per 100,000 children.
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